Jul 302012
 

We’re back in Philly, well, Parkesburg, PA for the night, but Philadelphia tomorrow for Sasha’s second treatment in the Mason Bone Cancer Study at the University of Pennsylvania.  We drove up to Pennsylvania from Raleigh, NC today, and we are spending the night at my parent’s home.  We’ll head to UPenn tomorrow at about 7AM in hopes of getting there at 9AM to meet with Dr. Mason.

Sasha has been doing well; full of life and spunk.  She did great the last time she was in Dr. Mason’s care, and I expect everything to go well this time, too.  Dr. Mason is excited to see Sasha, and, apparently, so are some of the other staff at the UPenn Vet School.  It seems that Sasha has earned a bit of a celebrity status at the school.

Liliana and I are planning to visit the University of Pennsylvania Museum of Archaeology and Anthropology tomorrow after dropping Sasha off with Dr. Mason, but I’ll be sure to write an update on how our visit at UPenn goes, and I’ll also introduce you all to a beautiful dog named Dolly.  Dolly is scheduled to be the third dog to participate in the Mason Bone Cancer Study.

Jul 272012
 

Molly - Mason Bone Cancer StudyMolly, the second dog in the Mason Bone Cancer Study, just finished her stay at UPenn with Dr. Mason.  Her owner, Jenn, says that Molly was fairly comfortable during her stay at the hospital.  She received the L. Monocytogenes vaccine on Tuesday, July 24.  Molly’s temperature increased two degrees above normal as a result of the bacteria floating around in her system.  Jenn also said that Molly’s white blood cell count doubled, but her liver values remained normal.

Molly heads home to New Jersey today, but should return to Philadelphia in about three weeks for her second round of the vaccine. Thanks to Molly’s owner, Jenn, and Rebecca, Molly’s aunt, for the updates.  Here’s to hoping that Molly, and all the dogs in the Mason Bone Cancer Study, continue to do well and live long and happy lives!

Make sure you come back to read about Dolly, the third dog in the UPenn clinical trial!

Jul 262012
 

A while ago, on this post, I showed pictures of Shelby and Tommy going swimming.  Well I finally have the video uploaded and ready to view!

These two had a ton of fun, and Carlos and I enjoyed seeing them happy and having a good time.  It never ceases to amaze me, just how happy dogs can make us; one look at their happy face, and we have a smile on our face.

Anyhow, enjoy watching the “youngings,” have fun!

XO,

~ Liliana

Jul 222012
 

About a week has passed since we returned to Raleigh from Philadelphia, where Sasha received her first treatment in the Mason Bone Cancer Study.  She is doing extremely well!  Take a look at this video:

We took Sasha to our local vet on Wednesday to have blood drawn and sent to Dr. Mason at UPenn.  During her stay in Philadelphia, Sasha’s liver enzymes rose to above normal levels.  Click here to read about Sasha’s first treatment at UPenn.  Dr. Mason was not too concerned about the elevated enzymes, as this reaction to the vaccine was reasonably expected.

Christina, a wonderful veterinary technician at Brentwood Animal Hospital, our local vet’s office, was tasked with drawing Sasha’s blood.  She is a bit of a phlebotomy hotshot with a knack for finding good veins quickly.  Unfortunately, this time Christina did have some difficulty guiding a syringe into Sasha’s vein.  She switched from Sasha’s leg to her arm and quickly found her mark.  Sasha was ready to leave after being poked, and Christina had all the blood she needed to send to Dr. Mason.

Sasha’s blood arrived at UPenn the next day.  Tests were run, and Dr. Mason let us know that all of Sasha’s numbers looked good.  Her red and white blood cells were normal, as were her platelets, and her liver enzymes were falling nicely, too.  Dr. Mason even sent us a graph where she plotted Sasha’s liver enzyme values so that we could see the downward trend, visually.

Liver Enzymes Graph, Mason Bone Cancer Study

Dr. Mason explained that the probable cause for Christina’s difficulty in finding a good vein to draw blood from in Sasha was that she may have been dehydrated.  She said that the sample of blood showed that her proteins were within normal parameters but at the top end of normal.  She also said that Sasha’s sodium level was a little high.  High blood proteins and high sodium levels are indicators of possible dehydration.  Another possibility is that sometimes the vessels where chemotherapy drugs are administered can become damaged, and are difficult to draw blood from.

Dr. Mason told us that the article on the study in the Philadelphia Inquirer brought several more dogs forward, and her team is currently screening their tumors for the Her2/neu expression.  There are currently 7 recruits and 3 or 4 being screened.  We hope these dogs make it into the study, and that they all do as well as Sasha has done so far!  Good luck to all!

A Two Week Plan

 Posted by
Jul 172012
 

A month has passed since Carlos and I were going to the gym on a regular basis.  We both felt drained and weak while training.  It got to the point that neither of us looked forward to going to the gym.  Not only were we struggling with our workouts, but we weren’t eating as clean as we normally do.  Carlos and I discussed how we were feeling, and we both agreed we probably needed a little break from the gym.  A break is sometimes a good idea to regroup and gain energy; however, a break from the gym does not necessarily mean that we should have also taken a break from clean eating.  We were away from the gym for two weeks, and off our regular diet for just as long.  When we finally made it back to the gym, it didn’t last for long.  We had to leave Raleigh for a clinical trial that our dog, Sasha, was enrolled in at the University of Pennsylvania Veterinary School, more on that hereRead Sasha’s experience in the Mason Bone Cancer Studyhere.

My hope was to attend a gym in the Philly area and do the best we could to eat healthily.  However, it was a little harder than I would have hoped.  One, to use a gym we would have to pay $10 per person, and $20 a day was not something we felt we should spend given our current job situation.  The nutrition front was not easy, because we stayed with Carlos’ parents, and their eating habits are not even close to ours.  We could have chosen to eat out, but again, we did not want to spend more money than we needed to, and we could not really buy food and keep it refrigerated because my in-laws fridge was already overly full.  So, we tried to eat as mindfully as we could given the circumstances.  On Thursday, our last full day in PA, we went to the area where we used to live in PA.  We went looking for a farm store where we once bought some ice cream.  Even though we only had it once, we can honestly say it is the best ice cream we ever had!  We found the farm store, and of course, we treated ourselves to some of this deliciousness.  We also went to Bravo Pizza and shared a pepperoni roll and a small pepperoni and sausage stromboli.  Bravo’s used to be one of our favorite places to get take out when we lived in PA.  The owner knew us and he would always give us pepperoni knots as a treat for our dogs.  We didn’t used to eat this stuff much, nor did our dogs, trust me = )

Anyway.  I don’t feel good about failing to eat better or not having worked out at all.  So, I’m embarking on a 2-week training and nutrition plan.

As of Sunday, we started training and cleaned up our diet.  From Sunday 7/15/12 thru Sunday 7/29/12, we’ll be on a strict gym-going-clean-eating-plan.  Our training will consist more of circuit training to keep our heart rate up.  We will also use the rowing machine at the gym on our pull-days.  We want to incorporate some sprinting, and we’ll be walking the dogs at least once a day.  By sticking with this plan, we should see positive results, such as having more energy, and maybe losing a few pounds.  I know Carlos will; guys lose weight so much easier/quicker than women = )  I am happy that I have not gained back the 6 lbs. I lost prior to us taking the break!

The week of July 30th we are driving to Philadelphia for Sasha’s 2nd treatment in the Mason Bone Cancer Study.  This second trip, during the days we are in Philly, we hope to be able to be active.  Additionally, I already have a 3-day YMCA pass (for each of us) for a location near Carlos’ parents so that we can train while there.

I’ll share an update on this plan during the weekend.  In the mean time:

Source

Jul 152012
 

History was made on July, 10, 2012, when Sasha underwent her first round of treatment in the Mason Bone Cancer Study at the University of Pennsylvania School Of Veterinary Medicine.  The study takes a novel approach to fighting cancer using a recombinant L. monocytogenes vaccine to, hopefully,   cause anti-tumor activity of the body’s immune system.  Liliana and I drove to Pennsylvania with Sasha, Argus and Alli (the Three Musketeers) on Monday.  We are lucky that my parents still live in PA, so we had a place to lay our heads for the duration of Sasha’s stay at UPenn.

We met with Dr. Nicola Mason Tuesday morning.  I cannot say enough good things about Dr. Mason.  Entering Sasha into the first phase of a clinical trial was not an easy decision to make.  Allowing her to be exposed (intravenously) to Listeria monocytogenes bacterium and leaving her in the care of people that we do not know at a large University did not make the decision any easier, but Dr. Mason put our worries to rest and our minds at ease.  Whenever Liliana and I speak with Dr. Mason, we always feel that she genuinely cares about Sasha, and she makes a great effort to ensure that we understand everything that will happen during the trial.  She also called us several times each day while Sasha was in her care to give us updates about how our girl was doing.  We feel very fortunate to have been able to enroll Sasha in this innovative approach to treating bone cancer in dogs, humans, and other animals.

Administration of the Listeria monocytogenes vaccine began at about 2:00 PM on Tuesday and lasted approximately one hour.  The first sign of evidence that Sasha had been exposed to the ‘bug’ came a few hours later.  She developed a mild-to-moderate fever which peaked at 103.8 (normal temperature for dogs is 101.5) at around midnight.  The fever was easily kept under control with IV liquids and a fan blowing on Sasha.  The fever was a good sign, as it indicated that Sasha’s immune system recognized the Listeria, and was actively fighting it.

The idea behind the Mason Bone Cancer Study is to train Sasha’s immune system to find and attack cancer cells.   Normal cells divide by a process called mitosis.  Mitosis occurs at a regular rate, and each cell produces two identical daughter cells.  Cancer cells are essentially bad copies of parent cells.  The DNA of the parent cell is not replicated perfectly during mitosis, and mutant cells are born.  These mutant cells do not behave normally.  They do not die when they are supposed to – a process genetically hardwired into each normal cell called apoptosis.  Instead, cancer cells multiply, often at accelerated rates, and can form tumors.  Note: not all tumors are cancerous, and not all cancer cells form tumors, i.e. leukemia.  Unfortunately, the mutant cancer cells are not so different from normal cells that the body’s immune system recognizes them as a threat.

The Listeria bug used in the Mason Bone Cancer Study has been genetically modified to express a protein called, Her2/neu.  Sasha’s cancer cells also produce this same protein.  By injecting the Listeria into Sasha, the hope is to elicit an immune response.  Since the listeria used expresses the Her2/neu protein, Sasha’s immune system will become programmed to recognize the protein as a dangerous invader and attack it.  The hope is that her immune system will now also recognize any cancer cells in her body as dangerous invaders and attack them, as well.

The day after Sasha’s vaccination, bloodwork showed that she was mildly anemic and that her platelet count was lower than normal.  These counts returned to normal the following day.  Dr. Mason explained that the likely cause for the low platelet count was the vaccination caused her platelets to adhere to the lining of her blood vessels, thus removing them from the bloodstream, and causing the low reading from the collected blood.  The temporary low count of Sasha’s red blood cells (anemia) was probably due to her blood being diluted as a result of the intravenous fluids she received to keep her temperature in check the prior day.

More bloodwork was performed on July 12th.  The results showed that Sasha’s liver enzymes were on the rise.  Her elevated liver enzymes, ALT (Alanine transaminase) and AST (Aspartate transaminase), are likely elevated due to inflammation caused by the vaccine.  Similar findings were documented in human patients that received a comparable Listeria vaccination.  Dr. Mason told us that Sasha’s elevated liver enzymes were not something to be alarmed about but that they should be monitored.  She asked that we schedule an appointment with Sasha’s regular veterinarian, Dr. Neuenschwander, to do follow up bloodwork on Wednesday or Thursday of this week.

Dr. Mason said that Sasha was a trooper throughout her whole stay at UPenn, and took all of the poking and prodding in stride and without complaint.  The only sign that Sasha may have been feeling under the weather is that she did not seem to have much of an appetite.  Dr. Mason made several attempts to get Sasha to eat, including hand feeding her, but Sasha was not interested until she was presented with some yummy canned food.  Again, our gratitude to Dr. Mason for taking such good care of Sasha.

We are back home in Raleigh, NC now, and Sasha is doing great.  She is still being a little picky with her food; however, we believe that her appetite is fine.  Sasha is a smart girl, and she learned quickly that by turning her nose up to her regular kibble, she would be offered something tastier.   She retrieved her Kong flying disc several times this morning and was as fast as ever!  We hope to take her swimming sometime before the return trip to Philadelphia.

Thanks to everyone for reading about Sasha’s battle against cancer, and Dr. Mason’s innovative work.  Thanks to Dr. Mason and her team at UPenn School of Veterinary Medicine.  Thanks to my parents for providing me and  Liliana with food to eat and a place to sleep.  Thanks to Greg Goldberg (basically my brother-in-law) for staying at our home in Raleigh and taking care of our other dogs while we were away.

I will continue to chronicle Sasha’s progress here on Lili’s Notes.  Please come back to see how she’s doing!

PS.  I’m famous!  Check out this article about me and the Mason Bone Cancer Study in the Philadelphia Inquirer.

Update on Tommy

 Posted by
Jul 142012
 

Several weeks ago, I mentioned that we found a lump on Tommy’s lip, and we were taking him to the vet.  On June 4th, Dr. N. examined him, and even though his thoughts were that the lump was likely nothing to worry about, he suggested we be on the safe side and remove the lump, and get it biopsied.

We scheduled the appointment to remove the lump for that Wednesday, June 6th.  Prior to anesthetizing Tommy, a blood panel was ran, and his liver enzymes were very high.  Dr. N. opted to wait and ran other tests.  Again, the tests showed his liver enzymes were very high.  At this point, other tests were being ran and we would wait on having the lump removed until we learned more as to why his liver enzymes were high; Tommy was healthy other than for the lump.

When Carlos and I went to pick Tommy up, Carlos asked if a smear could be put on a slide for analysis.  The lump was oozing and bleeding a little, and Dr. N. managed to get some of that onto a couple of slides.  It was worth a shot.

In a week’s time, our vet called and informed us the lump was a benign histiocytoma.  What a relief!  I had read about how cancers in the mouth can be very aggressive, and after Sasha being diagnosed with osteosarcoma, I was very worried about Tommy.

Not only was the lump noting to worry about, but it has completely vanished!

Stay tuned for an update on Sasha, a video of Shelby and Tommy swimming, and an update on a 2-week training and nutrition plan!

Jul 062012
 

Early in the week I needed to come out with a way to cook a bunch of chicken I had along with some veggies I had not cooked.

This is what I made:

I started by cooking the chicken in a large dutch oven (I have limited pots/pans).  I used organic coconut oil.

I got all the veggies ready and stir fry them in the dutch oven with coconut oil.  I used broccoli, carrots, and zucchini.  I added about 1/4 c. of low sodium soy sauce and about 1/4 c. stir fry sauce I had.

While the veggies were cooking a little, I cut up the chicken into small pieces.  After about 5 minutes, I added the chicken and added a little more soy sauce and stir fry sauce.  Last I added 3/4 c. cooked brown rice.  Mix everything and serve = )

It came out really good, and its a great recipe to make for the week.  We got 6 servings out of the dish, 3 per person.

Ingredients:

2 lbs. of chicken (@ The Fresh Market)

2 bags of broccoli (@ TJ’s)

1/2 bag shredded carrots (@ TJ’s)

2 medium zucchinis (@ TJ’s)

3/4 c. of brown rice (@ Whole Foods)

low sodium soy sauce

stir fry sauce

Next time, I plan on adding some red and green peppers and mushrooms.  I think it would be really good to make it a little spicy.  I’ve been a  little sensitive to spicy food, so I skipped it = )

This is a dish I plan on making on a regular basis.  Perfect for lunch or even a mid-afternoon snack.  I am not one to freeze food, but I bet it would freeze OK, making it better if larger amounts are cooked.

Enjoy!

Jul 032012
 

Here is yet another essay I wrote for my English class.  I thought this essay was perfect because I’m working on getting fitter.  For a while I was doing a lot of cardio with little results.  I switched my training to training with heavy weights and saw results immediately.  This led me to write this essay.

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High Endurance Cardio Training vs. Training with Heavy Weights

Losing weight and getting in shape is not easy.  Attaining the body a person wants takes hard work and dedication.  It seems that every day more and more people, myself included, set goals for themselves to lose weight.  They set these goals with intentions of losing weight and getting leaner to look better, improve their health and increase their longevity.  The problem that many of these people face as they start their journey to better health and a better physique, is that they do not know where to begin.  Television, magazines, and the internet abound with so called experts who all proclaim to have the answers that everyone is seeking for the best way to achieve, “The dream body you have always wanted” or “six-pack abs in 14 days!”  These advertisements prey on an individual’s desire to look like the impossibly beautiful and toned models in advertisements, and to achieve results quickly.  Quick-result gimmicks aside, there are two main schools of thought about how to get healthy and attain an attractive physique: workouts that focus on high endurance cardio training, and training with heavy weights.  While both types of workouts provide countless benefits to the people who partake in them, I believe training with heavy weights is the best method to achieve lean, well-muscled, and healthy bodies.

High endurance cardio training, such as running, cycling, and rowing increases endurance and stamina.  Cardio training has also been linked to other benefits such as immune system health and short-term sense of wellbeing.  Additionally, cardiovascular training reduces the incidence of diabetes and cardiovascular disease, including high blood pressure and stroke.  These benefits of cardio training should never be discounted, and cardio exercise should always be seen as a worthwhile investment of time and effort; however, cardio training has its limitations and downsides.  For example, jogging, whether on a treadmill or pavement, places severe and repeated traumatic stress on bones and joints.  Over time, such stress can lead to injuries such as runner’s knee and shin splints.  I have experienced some of the negative effects of intense cardio training.  The static positions required for some group cycling classes, some last for several minutes at a time, cause me significant lower back pain.  This pain does not dissipate after the exercise session is over, but lasts for days after.

In comparison to cardio training, training with heavy weights has more health benefits and fewer downsides.  Like cardio, training with heavy weights is also beneficial in the prevention and reduction of diabetes and cardiovascular disease.  The benefits of weight training, however, extend beyond those of cardio training in several important aspects.  For example, lifting heavy weights slows the decline and disease progression associated with aging.  Another benefit of heavy weight training is strength.  Muscle strength is necessary for performing countless every-day activities such as pulling a gallon of milk out of the refrigerator, climbing a set of stairs, lifting a child from a car seat, and a multitude of other common physical tasks.  In fact, strong muscles are even necessary to perform most cardio type exercises such as running, rowing, and cycling.  Heavy weight training also reduces age related decline in bone density which can lead to osteoporosis, and it can help reduce the painful symptoms of osteoarthritis.  Heavy weight training causes bones to become more dense and strong over time, thus helping to reduce how prone an individual is to injuries such as bone fractures.  All of these benefits, as well as many others, amount to an increase in longevity.  I prefer exercising with heavy weights.  This approach to working out has enabled me to have strength and confidence in daily life.  I attribute the ease at which I am able to handle my large dogs and perform many tasks, which require significant body strength, to my five-day-a-week heavy weight workouts.

High endurance cardio training can help people achieve lower readings on their bathroom scales; however, the weight loss comes from a loss of both muscle and fat.  In fact, the majority of weight loss that a person will experience from cardio exercise will be from muscle loss.  This is less than ideal, as in the endeavor to get in better shape, and be healthier, one should aim to increase their lean body mass to body fat ratio.  Another shortcoming of cardio training as a primary way of improving one’s health and becoming leaner, is that as a person becomes accustomed to the effort expended performing cardio exercise, she will need to increase the intensity or length of her workouts.  More often than not, people will do neither, and they will continue to believe their cardio routine is as beneficial to them as it ever was.

Weight training does not have the same shortcoming as cardio training does in that one does not need to increase the amount of effort performed in order to continue to achieve positive results.  Instead of lifting weights for longer sessions to maintain and improve health and body composition, one only needs to change her routine.  Periodically changing the number of sets and reps of weight lifting exercises performed, and also switching out some exercises for others is all that one must do to continue to achieve favorable results.  After participating in high endurance cardio training classes several times a week for almost a year, I switched to a heavy weight training routine.  My experience with heavy weight training is that is has been very effective.  In eight weeks’ time, I have lost over ten pounds of body fat and dropped two dress sizes.

Cardiovascular exercise can be good for the mind.  Some of the benefits of cardio exercise include enhanced mood, improved learning ability and memory power, and reduced stress.  However, high endurance cardio training raises levels of adrenaline which increases blood pressure, heart and respiration rate.  This causes an increase of cortisol, a hormone that can promote weight gain.  Furthermore, excess amounts of high endurance cardio training can lead to fatigue, anxiety, depression, insomnia, and frequent illness.  Cardio training can be beneficial if done in moderation, and as a second priority to weight training.  As an example, an instructor of several high endurance cardio classes, teaches a minimum of two or three classes a day.  Even though the instructor’s energy seems high, she often complains of being tired, and is often sick.

Training with heavy weights offers many of the same benefits to people as cardio training, but with fewer short comings.  Heavy weight training increases oxygen levels in the brain by increasing blood flow.  The increased oxygen along with elevated levels of certain chemicals in the body, result in improved attention, memory and speed of thinking, all of which are highly beneficial for people in everyday life.  It also reduces stress hormones like cortisol and is helpful in relieving symptoms of depression by stimulating feel-good hormones.  The increase of these hormones makes people feel happier and more confident.  Being strong helps people achieve more mentally and physically.  After training with heavy weights, I feel strong, confident, and ready for the rest of my day, whereas with cardio workout, I feel physically and mentally depleted after a forty-five minute session.

Whether training with heavy weights or performing high endurance cardio training, positive results and benefits can be attained by anyone who participates in any exercise routine, rather than living a sedentary life.  Even with the many benefits noted from high endurance cardio training, training with heavy weights is the best choice to lose fat, get leaner, improve health, and increase longevity.

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As always, feel free to provide feedback (constructive criticism).